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Phentermine; topiramate moderate serum digoxin auc was decreased by 12 when coadministered with topiramate.
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Digoxin is used to treat heart failureusually along with other medicationsIt is also used to treat certain types of irregular heartbeatsuch as chronic atrial fibrillationTreating heart failure may help maintain your ability to walk and exercise and may improve the strength of your heartTreating an irregular heartbeat can decrease the risk for blood clotsan effect that may reduce your risk for a heart attack or stroke.
Before using digoxintell your doctor if you have certain heart conditionsespeciallyAV blockunless you have a pacemakeror a recent history of heart attackAlso tell your doctor if you have kidney diseasea thyroid disorderan electrolyte imbalancesuch as low levels of calciumpotassiumor magnesium in your bloodor if you are malnourished or have recently been sick with vomiting or diarrhea.
Take the missed dose as soon as you remember itHoweverif it is almost time for the next doseskip the missed dose and continue your regular dosing scheduleDo not take a double dose to make up for a missed one.
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colchicine major according to the manufacturer of colcrys, both digoxin and colchicine are substrates of p-glycoprotein pgp and rhabdomyolysis has been reported in patients on concurrent therapy.