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Although no causal relationship with REVIA is suspectedphysicians should be aware that treatment with REVIA does not reduce the risk of suicide in these patientssee PRECAUTIONS

Irrespective of the drug chosen to reverse REVIA blockadethe patient should be monitored closely by appropriately trained personnel in a setting equipped and staffed for cardiopulmonary resuscitation.

When coadministered with morphineon a chronic basisREVIA blocks the physical dependence to morphineheroin and other opioids.

It is recommended that the prescribing physician relate the following information to patients being treated with REVIA:

A flexible approach to a dosing regimen may need to be employed in cases of supervised administrationThuspatients may receive 50 mg of REVIA every weekday with a 100 mg dose on Saturday100 mg every other dayor 150 mg every third dayThe degree of blockade produced by REVIA may be reduced by these extended dosing intervals.

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