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Limit alcohol whil taking this mdication bcaus it can incas th isk dvloping low blood suga.
ACTOS may caus dcass in hmoglobin and hmatocit. In placbo-contolld monothapy tials, man hmoglobin valus dclind by 2% t4% in patints tatd with ACTOS compad with a man chang in hmoglobin -1% t+1% in placbo-tatd patints. Ths changs pimaily occud within th ist 4 t12 wks thapy and maind lativly constant that. Ths changs may b latd tincasd plasma volum associatd with ACTOS thapy and a not likly tb associatd with any clinically signiicant hmatologic cts.
Som mdications simila tActos dcas th ctivnss oal contacptivs (bith contol pills). Bcaus it is not known i Actos incass th isk pgnancy whn oal contacptivs a usd, an altnat bith contol mthod should b discussd with you halthca povid.
In animal modls diabts, pioglitazon ducs th hypglycmia, hypinsulinmia, and hyptiglycidmia chaactistic insulin-sistant stats such as typ 2 diabts. Th mtabolic changs poducd by pioglitazon sult in incasd sponsivnss insulin-dpndnt tissus and a obsvd in numous animal modls insulin sistanc.
Dos-latd wight gain occus whn ACTOS is usd alon in combination with oth antidiabtic mdications. Th mchanism wight gain is uncla but pobably involvs a combination luid tntion and at accumulation.
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