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Beta-blockers controlled and uncontrolled domestic studies suggest that concomitant use of cardizem and beta-blockers is usually well tolerated, but available data are not sufficient to predict the effects of concomitant treatment in patients with left ventricular dysfunction or cardiac conduction abnormalities.

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The following postmarketing events have been reported infrequently in patients receiving CARDIZEMacute generalized exanthematous pustulosisallergic reactionsalopeciaangioedemaincluding facial or periorbital edemaasystoleerythema multiformeincluding Stevens-Johnson syndrometoxic epidermal necrolysisextrapyramidal symptomsgingival hyperplasiahemolytic anemiaincreased bleeding timeleukopeniaphotosensitivityincluding lichenoid keratosis and hyperpigmentation at sun-exposed skin areaspurpuraretinopathymyopathyand thrombocytopeniaThere have been observed cases of a generalized rashsome characterized as leukocytoclastic vasculitisIn additionevents such as myocardial infarction have been observedwhich are not readily distinguishable from the natural history of the disease in these patientsA definitive cause and effect relationship between these events and CARDIZEM therapy cannot yet be establishedExfoliative dermatitisproven by rechallengehas also been reported.

In mandiltiazem prevents spontaneous and ergonovine-provoked coronary artery spasmIt causes a decrease in peripheral vascular resistance and a modest fall in blood pressureand in exercise tolerance studies in patients with ischemic heart diseasereduces the heart rate-blood pressure product for any given workloadStudies to dateprimarily in patients with good ventricular functionhave not revealed evidence of a negative inotropic effectcardiac outputejection fractionand left ventricular end-diastolic pressure have not been affectedThere are as yet few data on the interaction of diltiazem and beta-blockersResting heart rate is usually unchanged or slightly reduced by diltiazem.

Exertional Angina Pectoris Due to Atherosclerotic Coronary Artery Disease or Angina Pectoris at Rest Due to Coronary Artery Spasm.

Cardizem CD 180 and 240 mg capsules containDiltiazem hydrochloride 180 mg or 240 mgfumaric acidpurified talcnon-pareil seedssucrosecolloidal anhydrous silicawhite beeswaxethylcellulosecastor oilstearic acidmethacrylic acid copolymerstributyl acetylcitratesimethiconegelatinbrilliant blue FCFblack iron oxide and titanium dioxide.

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