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Patients between 40 to 70 years of agepresenting with clinical signs and symptoms of SandhivatavizShulajoint painshothajoint-swellingstambhastiffnesssparsha asahyatatendernesssphutanacrepitusakunchana prasarana vedanapain during flexion and extension of the jointetc and patients without any anatomical deformity were included.
OsteoarthritisOAis the most common form of arthritiswhich is degenerative in natureIt is characterized by progressive disintegration of articular cartilageformation of new bone in the floor of the cartilage lesionseburnationand at the joint marginsosteophytesand leads to chronic disability at older ages1Clinical manifestations of OA range from mild to severeand affect the joints in hands and weight bearing joints such as kneeshipsfeet and spineOA is a clinical syndrome characterized by joint paintendernesslimitation of movementscrepitusoccasional effusion and variable degrees of inflammation without systemic effects2According to epidemiologythe prevalence of OA in India is 22-39Radiographic evidence of OA is present in majority of people over age 65among them80people are over 75 yearsApproximately11of those over 65 have symptomatic OA of the kneeIn India5.3males and 4.8females are aged more than 65 years3OA strikes women more often than men and it increases in prevalenceincidence and severity after menopauseThe etiology of OA is multifactorialVarious morphological as well as biochemical changes result in a softenedulcerated and malfunctioning articular cartilage4It has been postulated that agegenderbody weightrepetitive trauma and genetic factors are the risk factors which play an important role in the manifestation of OA5]
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Shallaki possesses tiktabittermadhurasweetand kashayaastringentrasatastegunaqualityof Shallaki is rukshadrylaghulightand tikshnavipakapost-digestive effectis katupungentwhereas viryastrength or effectis ushnaThe doshakarma is kapha-pitta shamakaAccording to classicsShallaki has potent vata-kaphahara properties7,8The key constituents of Shallaki are volatile oil4-8acid resin56-65and gum20-36The triterpenoids are the active constituents and are collectively called boswellic acidsThe gum resin of Bserrata usually contains 43boswellic acidswhich contain a combination of six major constituentsmainly 3 acetyl11 ketoboswellic acidsAKBAwhich help to preserve the structural integrity of joint cartilage and maintain a healthy immune mediator cascade at a cellular level9which is active against pain and inflammation by inhibiting leukotriene synthesisSpecificallyit inhibits the activity of the enzyme 5 lipoxygenase through a non-redox reaction in OA10]
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