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Dos-dpndnt inhibition platlt agggation can b sn 2 hous at singl oal doss clopidogl. patd doss 75 mg clopidogl p day inhibit ADP-inducd platlt agggation on th ist day, and inhibition achs stady stat btwn Day 3 and Day 7. At stady stat, th avag inhibition lvl obsvd with a dos 75 mg clopidogl p day was btwn 40% and 60%. Platlt agggation and blding tim gadually tun tbaslin valus at tatmnt is discontinud, gnally in about 5 days.
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Ac: Th pvalnc CYP2C19 allls that sult in intmdiat and poCYP2C19 mtabolism clopidogl dis accoding tac/thnicity. om litatu, limitd data clopidogl in Asian populations a availabl tassss th clinical implication gnotyping this CYP on clinical outcom vnts.
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patients treated with atorlip had an adverse experience profile generally similar to that of patients treated with placebo.