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Exelon has granted the underwriters a 13-day option to purchase up to 3,000,000 additional equity units upon the same terms.

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Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficulty breathingswelling of your facelipstongueor throat.

Mild to moderate Alzheimer’s DiseaseOralInitial dose1.5 mg orally twice a day with morning and evening mealsMaintenance doseAfter a minimum of two weeks of treatmentif the initial dosage is well toleratedit may be increased to 3 mg twice a daySubsequent increases to 4.5 mg and 6 mg twice a day should be attempted only after a minimum of 2 weeks at the previous dosageTransdermalInitial Dose4.6 mg/24 hour transdermal patch applied to the skin once daily Maintenance DoseAfter a minimum of four weeks of treatment and if well toleratedthe dose of the patch can be increased to 9.5 mg/24 hours for as long as this dose is beneficialThe dose can then be increased to 13.3 mg/24 hoursMaximum Dose13.3 mg24 hour transdermal patch applied to skin dailyHigher doses confer no appreciable additional benefitand are associated with significant increase in the incidence of adverse eventsCommentApply once a dayPress down firmly for 30 seconds until edges stick wellUse upper or lower back as the site of applicationDo not apply to skin area where creamlotionpowder has been recently appliedDo not apply to skin that is redirritatedor cutWear one patch at a timeChange site of application dailydo not apply a new patch to same location for at least 14 daysMay wear patch during bathingbut avoid long exposure to external heat sources.

There are no adequate and well-controlled studies in pregnant womenReproduction studies conducted in pregnant rats and rabbits at oral doses up to 2.3 mg-base/kg/dayor 2ratand 4rabbittimes the maximum recommended human doseMRHDof 12 mg per day on a mg/m 2 basisrevealed no evidence of teratogenicityBecause animal reproduction studies are not always predictive of human responsethis drug should be used during pregnancy only if clearly needed.

Overdosage with cholinesterase inhibitors can result in cholinergic crisis characterized by severe nauseavomitingsalivationsweatingbradycardiahypotensionrespiratory depressioncollapse and convulsionsIncreasing muscle weakness is a possibility and may result in death if respiratory muscles are involvedAtypical responses in blood pressure and heart rate have been reported with other drugs that increase cholinergic activity when coadministered with quaternary anticholinergics such as glycopyrrolateAdditional symptoms associated with rivastigmine overdose are diarrheaabdominal paindizzinesstremorheadachesomnolenceconfusional statehyperhidrosishypertensionhallucinations and malaiseDue to the short half-life of rivastigminedialysishemodialysisperitoneal dialysisor hemofiltrationwould not be clinically indicated in the event of an overdose.

Exelonrivastigmineimproves the function of nerve cells in the brainIt works by preventing the breakdown of a chemical that is important for the processes of memorythinkingand reasoningPeople with dementia usually have lower levels of this chemical.

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