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Clozaril can cause severe dizzinessslow heartbeatsfaintingor seizuresDo not take more of this medicine than recommendedBe careful if you drive or do anything that requires you to be alertAvoid getting up too fast from a sitting or lying positionor you may feel dizzyDizziness or severe drowsiness can cause fallsfracturesor other injuries.
If you miss your doses for longer than a day or twoconsult your doctor for a new schedule to get back to the dose you were onsee Missed Dose sectionUse this medication regularly in order to get the most benefit from itTo help you rememberuse it at the same time(seach day.
CommentsThe absolute neutrophil countANCmust be 2000/mm3 or greater and WBC count 3500 mm3 or greaterprior to initiating treatmentthe ANC and WBC must be monitored regularly during therapyA low starting dosegradual titrationand divided doses are necessary to minimize the risk of orthostatic hypotensionbradycardiaand syncopeWhen therapy is interrupted for 2 or more daysre-initiate with 12.5 mg once or twice a daybased on tolerabilitya dose that is restarted may be increased to a previously therapeutic dose more quickly than it was for initial treatment.
Clozaril can cause severe dizzinessslow heartbeatsfaintingor seizuresDo not take more of this medicine than recommended
At each consultationa patient receiving Clozaril must be reminded to contact the treating physician immediately if any kind of infection begins to developParticular attention should be paid to flu-like complaints such as fever or sore throat and to other evidence of infectionwhich may be indicative of neutropeniaPatients and their caregivers must be informed thatin the event of any of these symptomsthey must have a blood cell count performed immediatelyPrescribers are encouraged to keep a record of all patientsblood results and to take any steps necessary to prevent these patients from accidentally being rechallenged in the future.
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