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Mild to moderate peripheral edematypically associated with arterial vasodilation and not due to left ventricular dysfunctionoccurs in about one in ten patients treated with ProcardianifedipineThis edema occurs primarily in the lower extremities and usually responds to diuretic therapyWith patients whose angina is complicated by congestive heart failurecare should be taken to differentiate this peripheral edema from the effects of increasing left ventricular dysfunction.

Nifedipine was administered orally to rats for two years and was not shown to be carcinogenicWhen given to rats prior to matingnifedipine caused reduced fertility at a dose approximately 30 times the maximum recommended human doseThere is a literature report of reversible reduction in the ability of human sperm obtained from a limited number of infertile men taking recommended doses of nifedipine to bind to and fertilize an ovum in vitroIn vivo mutagenicity studies were negative.

Store at room temperatureProtect from lightStore in a dry placeDo not store in a bathroomKeep all drugs in a safe placeKeep all drugs out of the reach of children and petsThrow away unused or expired drugsDo not flush down a toilet or pour down a drain unless you are told to do soCheck with your pharmacist if you have questions about the best way to throw out drugsThere may be drug take-back programs in your area.

FDA pregnancy category CIt is not known whether nifedipine will harm an unborn babyTell your doctor if you are pregnant or plan to become pregnant while using this medication

Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficult breathingswelling of your facelipstongueor throat.

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